Dr Ohno-Machado received her medical degree from the University of São Paulo and her doctoral degree in medical information sciences and computer science from Stanford University. She is associate dean for informatics and technology, and the founding chair of the University of California San Diego (UCSD) Health Department of Biomedical Informatics, where she leads a group of faculty with diverse backgrounds in medicine, nursing, informatics and computer science. Before her current position, she was on faculty at Brigham and Women’s Hospital, Harvard Medical School and at the Harvard-MIT Division of Health Sciences and Technology. Dr Ohno-Machado is an elected fellow of the American College of Medical Informatics, the American Institute for Medical and Biological Engineering and the American Society for Clinical Investigation. She served as editor-in-chief for the Journal of the American Medical Informatics Association from 2011 to 2018. She directed the patient-centered Scalable National Network for Effectiveness Research, a clinical data research network with over 24 million patients and 14 health systems, as well as the NIH/BD2K-funded Data Discovery Index Consortium. She was one of the founders of UC-Research eXchange, a clinical data research network that connected the data warehouses of the five University of California medical centres. She now leads the California Precision Medicine Consortium for the All of Us Research Program, the RADx-rad Data Coordinating Center and research projects in the areas of privacy technology and data sharing.