Dr. Wagner is a Principal Investigator at The Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital, and Assistant Professor in the Departments of Pediatrics and Biomedical Informatics at the Ohio State University College of Medicine. Dr. Wagner serves as director of the Variant Interpretation for Cancer Consortium (VICC) Driver Project, co-lead of the NIH Bridge2AI Standards working group, and a member of the HGVS Variation Nomenclature Committee. He is a proponent of open science, FAIR data sharing, and AI-assisted scalable variant interpretation.
Dr. Wagner has co-developed several precision medicine web tools, including the Drug-Gene Interaction Database (DGIdb), the database of Clinical Interpretations of Variants in Cancer (CIViC), and the VICC meta-knowledgebase. His research continues to explore new models and tools to address the challenges of variation
and genomic knowledge representation, including his work as a product lead of the GA4GH Variation Representation Specification (VRS) and the VICC Gene Fusion specification (fusions.cancervariants.org). His research is focused on the development of tools and standards for advancing genomic medicine and our knowledge of genomic alterations in cancers, and his laboratory is actively involved in efforts to apply these
standards and tools to drive clinical variant interpretation at scale.