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Promoting schema alignment across multiple datasets owned and maintained by various institutes is necessary to perform large-scale federated search and analysis of biomedical data. In order to obtain this alignment, data providers must ensure their schemas are easily discoverable and accessible.

Here, we propose the idea for a new GA4GH standard, a “Schema Registry Service API,” which provides standardized methods for investigating, obtaining, and sharing biomedical schemas with the research community. We envision this API being adopted by multiple data curation institutes to promote a decentralized network of schema repositories.