De novo translocations at meiotic double-strand breaks in mice

Genome-wide mapping of LINE-1 elements and their methylation states through targeted long-read sequencing

A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer

Germline Mutation Rate is Genetically Controlled and Associated with Subfertility in the Collaborative Cross

MuTopia: decoding mutational processes in their genomic context

Detection of homologous recombination deficiency mutational signatures using adaptive sampling

The fate of mutations in Arabidopsis mitochondrial and plastid genomes

Genome-wide analysis of DNA DSB repair mechanisms and how they affect plant genome evolution in Arabidopsis thaliana

Automated Protocol for Discovering Crucial Mutations in Coronaviruses Using AI: Insights into Immune Escape and Resistance

Comprehensive whole-genome sequencing uncovers the origins of mutational signatures linked to aging, mismatch repair deficiency, and temozolomide chemotherapy.

Population-enriched germline variants in Finns pinpoint shared mechanisms shaping hematopoietic mosaic chromosomal alterations and diverse solid tumors

Origins and landscape of LINE-1 retrotransposition-induced somatic mosaicism in human normal cells revealed by PacBio long-read sequencing

Somatic genome changes in single canine neurons across lifespan

Contributing factors to the oxidation-induced mutational landscape in human cells

Single-Cell Analysis of Somatic Mutations in Human Brain and Skeletal Muscle During Aging

Contribution of mutation to the evolution of plant immune receptors

Epigenomic evolution during tumorigenesis

Evolutionary Trajectories of Metastatic Leiomyosarcoma Revealed Through Polyguanine Fingerprinting and Whole-Exome Sequencing

Genomic instability and mitochondrial dysfunction drive high grade serous ovarian cancer

An evolutionary model to explain differences in metastatic diversity across cancer types

Positive and negative subclonal selection in clear cell renal cell carcinoma

Unraveling the Contribution of Mutational Rate Variation to Observed Patterns of Functional Mutations in Human Cancer

Mutational signatures reveal the age of onset of homologous recombination deficiency before cancer diagnosis

Individual Somatic Natural History of Human Bone Marrow Cell Types

Regulatory Genomics and Cancer Evolution

Ancestry-Driven Cardiovascular Insights: Systematic Evaluation of Short-Read RNA-Seq of MECA Participants

DNA repair gene variants and chemotherapy shape clonal diversity in human monocytes

Simultaneous mapping of somatic mosaicism and 3D genome in single cell

Comparative Multiomics Landscape of Hereditary Vs. Sporadic Adrenocortical Carcinoma

Disentangling Composite Mutational Signatures through Explicit Modeling of Correlations

Tracing Epigenetic Changes Across the Human Lifetime

Genomic mosaicism reveals the evolutionary history and selection of Cavendish bananas

Reconstructing human colon development: Insights from spatial genomics and single-crypt phylogenies

Somatically acquired tandem repeat length variations across the human lifetime

Tau: A Generalized Analytical Framework for Mutation Timing Across All Copy Number States

Error corrected sequencing approaches to identify de novo structural variant mutations and their timing

Comparison of mutation rates between haploid and diploid cells of the fission yeast Schizosaccharomyces pombe as a test of the drift barrier hypothesis

Genome-wide somatic L1 insertion profiling using PTA HAT-seq

Increased rate of de novo single nucleotide mutations in house mice born through assisted reproduction.

Investigating clonal haematopoiesis using a novel single cell multi-omic
approach

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

Estimating historical tumor growth rates from bulk DNA sequencing data using clock-like mutation signatures and variant allele frequencies

The origin of clonal hematopoiesis can be traced to prenatal development

Using extended sequence context to improve cancer type prediction

Rapid and highly variable mutagenesis of complex tandem repeats identified across four generations of a large Utah pedigree

Quantifying ‘just-right’ APC inactivation for colorectal cancer initiation

The impact of age-associated clonal hematopoiesis in breast cancer metastatic relapse.

Bayesian ancestral state reconstruction provides insight into complex histories of somatic evolution

Mutation rate-free driver detection in human cancer

Detection of de novo mutations in primate testis and human sperm samples from HiFi sequencing

Hippocampal Somatic Evolution Mediated by Ras-MAPK Mosaicism in Drug-Resistant Epilepsy

Gene Expression Networks Associated with APOBEC3 Mutational Signature in Cancer

Systematically understanding the relationship between DNA methylation changes and genomic instability in cancer

Variation in Somatic Mutational Processes Across Pre- and Post-Natal Development in Matched Human Heart and Brain

Using sequence context and genomic features to predict site-specific mutation rate

A Novel Long-Read Sequencing Method to Detect Complex L1 Insertions

Evolutionary dynamics and patterns of lymphatic metastasis in gastric cancer

Adaptive Clonal Evolution Shapes Brain Development and Mosaicism

Evolutionary rescue by aneuploidy in tumors exposed to anti-cancer drugs

Resistance mechanisms in recurrent/metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) patients treated with cetuximab and nivolumab

numbat-multiome: A CNV-centered view of genetic and epigenetic changes associated with tumor phenotypes

Methyl-CODEC enables simultaneous methylation and duplex sequencing

Population genomics of adaptive evolvability in Arabidopsis

DERMATLAS: Mapping the Mutational Landscape of Skin Tumours

Evolution and Mutation Dynamics of Antimicrobial Resistance in Streptococcus suis

Towards understanding the molecular mechanisms behind H3K4me1-driven genomic mutation bias

When the Smoke Clears: Cancer-like epigenetic reprogramming of normal bronchial epithelium

Tracing somatic evolution of the normal colon in early-onset colorectal cancer

A Model for Recessive Mutation Rate Modifiers

Interactions between sequence context and methylation shape germline CpG mutation rate variation across the human genome

Multiple Copy Effect of Somatic Mutations Enhances Mutant Establishment by Overcoming Loss by Genetic Drift

Somatic mutation landscapes in healthy tissues of individuals with inherited BRCA-mediated DNA repair deficiency

Discovering Low-Frequency Somatic Mutations in a Craniofacial Microsomia Patient Using RUFUS: A Reference-Free, Kmer-Guided Detection Algorithm

An algorithm identifies transposon insertions and their hotspots inside the existing copies

A sibling study of parental mutation rates

Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in spermatogonia

Uncovering the timing and origins of de novo mutations in the offspring and placenta of rhesus macaques

Phylogenetic Analysis of Ovarian, Gastric, and Pancreatic Cancers Reveals Distinct Evolutionary Patterns and Clonal Dynamics in Peritoneal Metastasis

APOBEC3A, not APOBEC3B, drives deaminase-associated mosaicism in human gastric epithelium

Dissecting the interaction between Immune Microenvironment and Evolutionary Dynamics in Early-Stage Ovarian Clear Cell Carcinoma

De novo mutation data support unequal contributions from at least 7 founding primordial germ cells to the adult human gamete pool

Phenotyping somatic mosaicism in steatotic liver disease