The genome encodes the basic blueprints and switches underlying everything a cell does, but it's the proteome — the cell's collection of proteins — that does the work of carrying signals, turning circuits on and off, processing energy, and more. How do researchers study the proteome, and how does that knowledge translate into new approaches to treating disease? Research scientist Namrata Udeshi and physician-scientist Michael Gillette will take us on a tour of the proteome and some of the opportunities that the science of proteomics presents for advancing human health.