Symposium on Severe Mental Illness: On The Frontier Of Translational Neuroscience

Tuesday, September 21 and Wednesday, September 22, 2021

12:00 PM - 12:45 PM
KEYNOTE

ADOLESCENT BRAIN DEVELOPMENT AND RISK FOR PSYCHOSIS: UNDERSTANDING PATHWAYS AND POTENTIAL MECHANISMS
Deanna Barch, Washington University in St. Louis

12:45 PM - 2:15 PM
SESSION ONE

Genes, circuits and behavior 
Chair: Guoping Feng

12:45   Prefrontal cortical maturation during adolescence in mouse and marmoset
             Kevin Mastro, Stevens/Sabatini labs, Boston Children's Hospital

1:00     Probing genetic mouse models of cognitive dysfunction to better understand attention
             Brielle Ferguson, Stanford University

1:15    Anterior thalamic dysfunction underlies cognitive deficits in neuropsychiatric disease models
             Dheeraj Roy, Feng lab, Broad Institute

1:30    Walking the translational talk: A face and construct valid primate model of autism
             Karen Parker, Stanford University

1:45    The brain in motion- How ensemble fluidity supports memory-updating
             Denise Cai, Mt Sinai

2:00     Q&A

2:15 PM - 3:00 PM
SPOTLIGHT

BRIDGING THE GAP BETWEEN INNATE AND LEARNED: A PARENT’S ROLE IN PROMOTING SURVIVAL
Bianca Jones Marlin, Columbia University

3:00 PM - 3:15 PM
Coffee Break
 
3:15 PM - 4:45 PM
SESSION TWO

Genetics of mental illness 
Chair: Ben Neale

3:15     Hot Flash: A GWAS with notable interpretability and psychiatric relevance
             Laramie Duncan, Stanford University

3:30     Expansion of phenotyping and sequencing efforts provide insights into the psychosis spectrum
             TJ Singh, Daly lab, Broad Institute/MGH

3:45    Biological insights from genetic studies of bipolar disorder
             Niamh Mullins, Mt Sinai

4:00     Low generalizability of polygenic scores in African ancestry populations
             Lerato Majara, Martin lab, Broad Institute/University of Cape Town

4:15     Panel Discussion

9:00 AM - 9:45 AM
KEYNOTE

NEURONAL PROTEIN SUPPLY AND DEMAND
Erin Schuman, Max Planck Institute for Brain Research

9:45 AM - 10:00 AM
Coffee Break
 
10:00 AM - 11:45 AM
SESSION THREE

Therapeutic mechanisms and disease biomarkers
Chair: Jen Pan

10:00   BDNF receptor TRKB as a direct target for antidepressant drugs 
             Eero Castrén, University of Helsinki

10:15   A novel approach for studying gamma band coherence in transgenic mouse models
             Jean Carlos Rodríguez Díaz, Jones lab, University of Michigan

10:30   Probing and rescuing dysfunctional brain circuits in depression
             Conor Liston, Cornell University

10:45   NPTX2 loss of function and schizophrenia
             Mei-Fang Xiao, Worley lab, Johns Hopkins University

            Synaptic trafficking of the immediate early gene NPTX2 in vivo
             Seung-Eon Roh, Worley lab, Johns Hopkins University

11:15     Panel Discussion

11:45 AM - 12:00 PM
Coffee Break
 
12:00 PM - 1:15 PM
SESSION FOUR

Computational psychiatry & big data approaches
Chair: Evan Macosko

12:00   The social brain: Models, molecules, and mental health
             Xiaosi Gu, Mt Sinai

12:15   Modeling neuronal identity changes with single-cell multimodal integration
             Joshua Welch, University of Michigan

12:30   Mapping brain cell organization with single-cell, single-virion genomics
             Arpiar Saunders, Oregon Health & Science University

12:45   Intrinsic neural timescales in schizophrenia
             Guillermo Horga, Columbia University

1:00   Q&A

1:15 PM - 1:55 PM
FIRESIDE CHAT

Kay Redfield Jamison, Johns Hopkins and Steven Hyman, Broad Institute

1:55 PM - 2:00 PM
CLOSING REMARKS AND THANKS