Symposium on Severe Mental Illness
From Genes to Mechanisms to Therapeutics
| 8:00 AM - 8:45 AM | BREAKFAST | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 8:45 AM - 8:55 AM | OPENING SESSION Welcome – Steve Hyman, Harvard University & Broad Institute | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 8:55 AM - 10:05 AM | KEYNOTE 8:55 Keynote Introduction – Steve Hyman, Harvard University & Broad Institute 9:05 Keynote: Humanizing drug discovery – David Altshuler, Vertex | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 10:05 AM - 12:25 PM | SESSION ONE Psychiatric genetics and genomics: Progress and challenges | Chair: Elise Robinson 10:05 Session Introduction – Elise Robinson, MGH & Broad Institute 10:40 Coffee Break 10:55 Functional convergence of common and rare variant risk for neuropsychiatric disease | Elise Robinson, MGH & Broad Institute 11:25 Psychiatric Genetics through the Lens of Neurodevelopmental Transcriptomics I Mike Gandal, University of Pennsylvania 11:55 The Biology of Adversity | Jason Buenrostro, Harvard University & Broad Institute | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 12:25 PM - 1:25 PM | LUNCH | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 1:25 PM - 5:00 PM | SESSION TWO Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery, Chair: Zhanyan Fu 1:25 Session Introduction | Zhanyan Fu, Broad Institute 1:30 Probing and rescuing dysfunctional brain circuits in depression | Conor Liston, Cornell University 2:00 Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor | Jonathan Weissman, MIT & Whitehead Institute 2:30 CRISPR-mediated bipolar disorder-associated gene deletion in sleep-regulating mouse neurons | Julie Kauer, Stanford 3:00 Coffee Break 3:15 Poster Session previews 3:40 Panel discussion on genetic medicine – addressing quantitative gene defects
4:50 Closing Remarks | Evan Macosko, HMS & Broad Institute | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 5:00 PM - 7:00 PM | STANLEY CENTER POSTER SESSION McGovern Institute Atrium | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 8:00 AM - 8:45 AM | BREAKFAST | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 8:45 AM - 9:55 AM | KEYNOTE 8:45 Keynote Introduction – Steve Hyman, Harvard University & Broad Institute 8:55 Keynote: Autoimmune psychosis – hope or hype? | Belinda Lennox, University of Oxford | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 9:55 AM - 12:00 PM | SESSION THREE Understanding mental illness mechanisms using human model systems and clinical cohorts - Chair: Evan Macosko 9:55 Session Introduction | Evan Macosko, HMS & Broad Institute 10:00 Characterizing the clinical impact of genetic variants in psychotic disorders using decades of longitudinal healthcare data | Olli Pietiläinen, University of Helsinki & Broad Institute 10:30 Developmental dysconnectivity in a genetic risk model for psychosis | Carrie Bearden, UCLA 11:00 Coffee Break 11:20 Fireside Chat: Humanizing mental illness: the power of stories | Lisa Genova with Steve Hyman, and Eliza T. Williamson, NAMI-MA | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 12:00 PM - 1:00 PM | LUNCH | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 1:00 PM - 3:30 PM | SESSION FOUR Frontiers of mechanistic and therapeutic discovery in the central nervous system - Chair: Randy Buckner 1:00 Session Introduction | Randy Buckner, Harvard University 1:05 Decoding cell-type-specific mechanisms in the human brain to guide therapeutic discovery | Panos Roussos, Icahn School of Medicine 1:35 Animal models of schizophrenia and bipolar disorder based on human genetics | Morgan Sheng, MIT & Broad Institute 2:05 Coffee Break 2:25 Panel Discussion – What do we need to get industry re-engaged?
3:15 Closing Remarks | Steve Hyman, Harvard University & Broad Institute, and Steve Paul, Seaport Therapeutics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||