Symposium on Severe Mental Illness

From Genes to Mechanisms to Therapeutics

8:00 AM - 8:45 AM
BREAKFAST
 
8:45 AM - 8:55 AM
OPENING SESSION

Welcome – Steve Hyman, Harvard & Broad Institute

8:55 AM - 10:05 AM
KEYNOTE

8:55     Keynote Introduction – Steve Hyman, Harvard & Broad Institute

9:05     Keynote  – David Altshuler, Vertex

10:05 AM - 12:20 PM
SESSION ONE

Psychiatric genetics and genomics: Progress and challenges - Chair: Elise Robinson

10:05     Ben Neale, MGH & Broad Institute 

10:35     Coffee Break

10:50     Elise Robinson, HSPH & Broad Institute 

11:20     Mike Gandal, University of Pennsylvania

11:50     Jason Buenrostro, Harvard University & Broad Institute 

12:20 PM - 1:20 PM
LUNCH
 
1:20 PM - 5:00 PM
SESSION TWO

Molecular and neural mechanisms of neuropsychiatric disorders - driving biomarker and therapeutic discovery, Chair: Zhanyan Fu

1:20     Session Introduction – Zhanyan Fu, Broad Institute

1:30    Conor Liston, Cornell University

2:00     Jonathan Weissman, MIT & Whitehead Institute  

2:30     Julie Kauer, Stanford 

3:00     Coffee Break

3:15     Poster Session previews

  • TBD

3:40     Panel discussion on genetic medicine – addressing quantitative gene defects

  • Moderator: Evan Macosko, HMS & Broad Institute 
  • Jonathan Weissman, MIT & Whitehead Institute 
  • Guoping Feng, MIT & Broad Institute  
  • Kelsey Martin, SFARI
  • Toby Ferguson, Voyager 

4:50     Closing Remarks 

5:00 PM - 7:00 PM
STANLEY CENTER POSTER SESSION
 
8:00 AM - 8:45 AM
BREAKFAST
 
8:45 AM - 9:55 AM
KEYNOTE

8:45     Keynote Introduction – Steve Hyman, Harvard & Broad Institute

8:55     Keynote – Belinda Lennox, Oxford University 

9:55 AM - 12:00 PM
SESSION THREE

Understanding mental illness mechanisms using human model systems and clinical cohorts - Chair: Evan Macosko

 9:55     Session Introduction – Evan Macosko, HMS & Broad Institute 

10:00    Olli Pietiläinen, University of Helsinki & Broad Institute

10:30     Carrie Bearden, UCLA

11:00     Coffee Break

11:20    Fireside Chat
            Lisa Genova with Steve Hyman

12:00 PM - 1:00 PM
LUNCH
 
1:00 PM - 4:30 PM
SESSION FOUR

Frontiers of mechanistic and therapeutic discovery in the central nervous system - Chair: Randy Buckner

1:00     Session Introduction – Randy Buckner, Harvard University 

1:05    Panos Roussos, Mount Sinai

1:35     Morgan Sheng, MIT & Broad Institute

2:05     Coffee Break

2:25    Panel Discussion – What do we need to get industry re-engaged? 

  • Moderator: Steve Hyman
  • Jane Grogan, Biogen
  • Fiona Elwood, J&J
  • Steve Paul, Seaport Therapeutics
  • James Cronican, Boehringer Ingelheim

3:15    Closing Remarks