8:30am - 9:00am
                                                                                                             

Registration

Merkin Lobby

9:00am - 9:30am

Welcome Remarks

Melina Claussnitzer, PhD

Director of the Broad Diabetes Initiative (BDI), Associate Director of Scientific Strategy for the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, and Institute Member at the Broad Institute of MIT and Harvard

Broad Auditorium

9:30am - 10:15am

Keynote: “AI-ML + Multiplex Libraries for New  Functions and New Therapies”

George Church, PhD, Professor of Genetics and Professor of Health Sciences and Technology, Director of the U.S. Department of Energy Technology Center and Director of the National Institutes of Health Center of Excellence in Genomic Science

Broad Auditorium

10:15am - 10:30am

Break

Merkin Lobby

10:30am - 11:30am

Session I: Scaling Variant Interpretation

Session Chair: Ditte Demontis, PhD, Professor of Psychiatric Genetics at Aarhus University, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute

Broad Auditorium

10:30am - 11:00am

“Genetic Subtypes of Obesity: A Shortcut to Function”

Ruth Loos, PhD, Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute

Broad Auditorium

11:00am - 11:30am

“Exploring Mechanisms Underlying the Human Phenome through Gene to Variant Approaches”

Jason Flannick, PhD, Assistant Professor of Pediatrics at Harvard Medical School and the Division of Genetics and Genomics at Boston Children’s Hospital, and an Associate Member of the Broad Institute of MIT and Harvard

Broad Auditorium

11:30am - 12:00pm

“Mapping Genetic Effects for High-Dimensional Molecular Phenotypes at the Single-Cell Level”

Wei Zhou, PhD, Assistant Professor, Center for Genomic Medicine of Massachusetts General Hospital and Harvard Medical School, Associate Member, Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard

Broad Auditorium

12:00pm - 1:00 pm

Lunch

Merkin Lobby

1:00pm - 2:00pm

Session II: Regulatory Landscapes and Gene Control

Session Chair: Bradley E. Bernstein, MD, PhD, Department Chair of the Cancer Biology Dana-Farber Cancer Institute, Director of the Gene Regulation Observatory and Director of the Human Gene Regulation Map in the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute, Professor of Cell Biology at Harvard Medical School

Broad Auditorium

1:00pm - 1:30pm 

“Learning Disentangled Representations of Single Nucleus Epigenomes for Variant Interpretation”

Jesper Madsen, PhD, Associate Professor of Computational Biology in the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute

Broad Auditorium

1:30pm - 2:00pm

“Mapping the Regulatory Wiring of the Genome to Link Variants to Functions”

Jesse Engreitz, PhD, Assistant Professor of Genetics at Stanford University, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute

Broad Auditorium

2:00pm - 3:00pm

Session III: Decoding Variant Effects through Cellular Maps

Session Chair: Tune H. Pers, PhD, Novo Nordisk Foundation Center for Basic Metabolic Research, Associate Professor at the University of Copenhagen, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute

Broad Auditorium

2:00pm - 2:30pm

“Single-cell Genomics Dissection of Common Immune Networks Driving Autoimmunity”
Alexandra-Chloé Villani, PhD, institute Member at the Broad Institute of MIT and Harvard, Assistant Professor of Medicine at Harvard Medical School, Principal Investigator at the Massachusetts General Hospital (MGH) Center for Cancer Research and Director of the Single Cell Genomics Research Program at the Center for Immunology and Inflammatory Diseases 

Broad Auditorium

2:30pm - 3:00pm

“Predicting Gene-Regulatory Function from DNA Sequence with Deep Learning”

Johannes Linder, PhD, Machine Learning Scientist at Calico Life Sciences LLC

Broad Auditorium

3:00pm - 3:15pm 

Break

Merkin Lobby

3:15pm - 5:00pm

Session IV: Translating Variants into Therapeutic Insights

Session Chair: Benjamin Neale, PhD, Core Institute Member, Co-director of the Stanley Center for Psychiatric Research and Associate Director Flagship Disease Projects in the NNFC for Genomic Mechanisms of Disease at the Broad Institute, Associate Professor at Massachusetts General Hospital and Harvard Medical School

Broad Auditorium

3:15pm - 3:45pm 

“Genetic Influences on Human Hematopoiesis”

Vijay Sankaran, MD, PhD, Professor of Pediatrics at Boston Children’s Hospital and Harvard Medical School, Investigator of the Howard Hughes Medical Institute

Broad Auditorium

3:45pm - 4:15pm

“Engineering Bespoke Genome Editing Therapies and Beyond”

Ben Kleinstiver, PhD, Associate Professor at Massachusetts General Hospital (MGH) and Harvard Medical School

Broad Auditorium

4:15pm - 5:00pm 

Keynote: "Placing billion-dollar bets: human genetics in drug R&D”.

Robert Plenge, MD, PhD, Executive Vice President and Chief Research Officer at Bristol Myers Squibb

Broad Auditorium

5:00pm - 7:00pm 

Poster Session and Reception

Merkin Lobby